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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

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Published on: December 2, 2022

Sector (partial) oculo(dermal) melanocytosis in 89 eyes.

Carol L Shields¹, Anam Qureshi, Arman Mashayekhi

¹Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. carol.shields@shieldsoncology.com

|October 25, 2011

Summary

Sectoral ocular melanocytosis, a partial uveal involvement, can occur and may be associated with uveal melanoma. No specific melanocytosis features were statistically linked to melanoma presence in this study.

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Area of Science:

Ophthalmology
Dermatology
Oncology

Background:

Ocular melanocytosis is a condition characterized by pigment cell proliferation.
Understanding its sectoral presentation and association with uveal melanoma is crucial for patient management.

Purpose of the Study:

To describe the sectoral (partial) involvement of the uvea in ocular melanocytosis.
To investigate the clinical features and relationship between ocular melanocytosis and uveal melanoma.

Main Methods:

Retrospective, noninterventional case series.
Analysis of medical records, color photographs, and ultrasound images from 89 eyes of 86 patients.
Evaluation of clinical features and association with uveal melanoma.

Main Results:

Sectoral melanocytosis affected a mean of 5-6 clock hours of the uvea, involving iris and/or choroid.
Uveal melanoma was present at diagnosis in 8% of patients.
Factors like male gender and scleral/choroidal melanocytosis showed potential associations with melanoma, but lacked statistical significance in this cohort.

Conclusions:

Ocular melanocytosis can present as a sectoral condition affecting the uvea.
Melanoma can manifest within the region of melanocytosis.
No specific melanocytosis features were found to be statistically significant predictors of melanoma presence.