Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Data Volume and the Need for Clinical Decision Support in Glaucoma Care.

Ophthalmology science·2026
Same author

Extraction of Glaucoma Diagnosis, Type, and Severity from Clinical Notes using Secure Cloud-based Large Language Models.

medRxiv : the preprint server for health sciences·2026
Same author

GLLaucoMed: A Secure LLM-Powered Agentic Workflow for Automated Medication Extraction from Free-Text Glaucoma Clinical Notes.

medRxiv : the preprint server for health sciences·2026
Same author

Optic Disc Fundus Images Retain Biometric Identity Signals Under Deep Learning.

Research square·2026
Same author

Development and Pilot Testing of a Mobile App Psychosocial Intervention for Psychological Distress in Individuals with Glaucoma.

medRxiv : the preprint server for health sciences·2026
Same author

Reply to Comment on "RNFL Thickness in a Population-Based Cohort: The Canadian Longitudinal Study on Aging M2M (Machine-to-Machine) Study".

American journal of ophthalmology·2026

Related Experiment Video

Updated: May 28, 2026

Corneal Sensitivity Testing Procedure for Ophthalmologic and Optometric Patients
04:00

Corneal Sensitivity Testing Procedure for Ophthalmologic and Optometric Patients

Published on: August 2, 2024

Association between corneal biomechanical properties and glaucoma severity.

Kaweh Mansouri1, Mauro T Leite, Robert N Weinreb

  • 1Hamilton Glaucoma Center, Department of Ophthalmology, University of California San Diego, La Jolla, USA.

American Journal of Ophthalmology
|October 25, 2011
PubMed
Summary

Corneal biomechanical properties measured by Ocular Response Analyzer show a weak association with glaucoma severity. Corneal resistance factor correlated with visual field defects, but corneal hysteresis did not, after adjustments.

Related Experiment Videos

Last Updated: May 28, 2026

Corneal Sensitivity Testing Procedure for Ophthalmologic and Optometric Patients
04:00

Corneal Sensitivity Testing Procedure for Ophthalmologic and Optometric Patients

Published on: August 2, 2024

Area of Science:

  • Ophthalmology
  • Biomechanical Engineering
  • Glaucoma Research

Background:

  • Glaucoma is a progressive optic neuropathy characterized by visual field loss.
  • Corneal biomechanical properties may influence intraocular pressure measurements and disease progression.
  • The Ocular Response Analyzer (ORA) measures corneal hysteresis (CH) and corneal resistance factor (CRF).

Purpose of the Study:

  • To investigate the association between corneal biomechanical parameters (CH and CRF) obtained via ORA and glaucoma severity.
  • To determine if ORA parameters correlate with functional (visual field) and structural (retinal nerve fiber layer) damage in glaucoma patients.

Main Methods:

  • An observational, cross-sectional study involving 191 patients (299 eyes) with confirmed or suspect glaucoma.
  • Corneal hysteresis (CH) and corneal resistance factor (CRF) were measured using the ORA.
  • Glaucoma severity was assessed using standard automated perimetry (visual field testing) and retinal nerve fiber layer (RNFL) thickness measurements (GDx ECC and SD-OCT).
  • Univariable and multivariable regression models were used to analyze the associations.

Main Results:

  • Both CH and CRF showed a positive association with mean defect (MD) in visual field tests.
  • In multivariable analysis, CRF remained significantly associated with MD, but CH did not.
  • A weak association between CH/CRF and average RNFL thickness was observed with GDx ECC, but not with SD-OCT.
  • After adjusting for central corneal thickness, age, and axial length, the associations between CH/CRF and RNFL thickness were no longer statistically significant.

Conclusions:

  • The study found a weak relationship between corneal biomechanical parameters and measures of structural and functional damage in glaucoma.
  • Corneal resistance factor may have a more consistent association with visual field damage than corneal hysteresis in glaucoma.
  • Further research is needed to clarify the role of corneal biomechanics in glaucoma pathogenesis and progression.