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An inversion truncating the creA gene of Aspergillus nidulans results in carbon catabolite derepression
H N Arst1, D Tollervey, C E Dowzer
1Department of Bacteriology, Royal Postgraduate Medical School, London, UK.
Molecular Microbiology
|May 1, 1990
Abstract:
The creAd-30 mutation leading to carbon catabolite derepression in Aspergillus nidulans is a pericentric inversion, having one breakpoint within the creA gene on the left arm of chromosome I and the other breakpoint between binG and yA on the right arm. The left-arm breakpoint alters the creA transcript. The likelihood that the inversion truncates creA centrally strengthens a previous proposal that derepression is the phenotype of loss-of-function mutations in creA.