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Molecular epidemiology, genome characterization, and recombination event of human parechovirus

Thaweesak Chieochansin1, Preeyaporn Vichiwattana, Sumeth Korkong

  • 1Center of Excellence in Clinical Virology, Department of Pediatrics, Chulalongkorng University, Bangkok, Thailand.

Virology
|October 25, 2011
PubMed

Insights

Human Parechovirus (HPeV) circulates widely in Thailand, affecting children and infants. This study found HPeV in respiratory and fecal samples, revealing diverse genotypes and significant recombination events.

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • Human Parechovirus (HPeV), a Picornaviridae family member, is a significant infectious agent primarily impacting pediatric populations globally.
  • Sixteen distinct HPeV genotypes have been identified, indicating widespread international dissemination.

Purpose of the Study:

  • To investigate the prevalence and genetic diversity of Human Parechovirus (HPeV) in Thailand.
  • To characterize HPeV genotypes and identify recombination events in collected samples.

Main Methods:

  • Analysis of 2957 nasopharyngeal (NP) swabs and 759 fecal samples from Thailand.
  • Detection of HPeV using molecular methods.
  • Genotyping and identification of recombination events in positive samples.

Main Results:

  • HPeV was detected in 0.4% of NP swabs and 6.1% of fecal samples.
  • Infections were most common in children under 2 years old, but also occurred in older children.
  • Genotypes 1A, 1B, 2, 3, 4, 5, 6, 10, and 14 were identified.
  • Recombination events were observed in 16 samples, with HPeV1B showing the highest frequency.

Conclusions:

  • Human Parechovirus (HPeV) is detectable in both the respiratory and gastrointestinal tracts.
  • The HPeV strains circulating in Thailand exhibit significant genetic diversity.
  • Recombination is a notable feature of HPeV epidemiology in the studied region.

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