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Updated: Aug 9, 2026

Analysis of Cell Cycle Position in Mammalian Cells
Published on: January 21, 2012
Domains of human c-myc protein required for autosuppression and cooperation with ras oncogenes are overlapping
L J Penn1, M W Brooks, E M Laufer
1Growth Control and Development Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, United Kingdom.
Abstract:
Amino acids 106 to 143 and 354 to 433 of the human c-myc protein (439 amino acids) were shown to be required for the protein to suppress c-myc gene transcription and were found to exactly overlap with those necessary for c-myc to cooperate with ras oncogenes in the transformation of rat embryo fibroblasts. The essential carboxyl-terminal region harbors structural motifs (a basic region, a helix-loop-helix motif, and a "leucine zipper"), which, in other proteins, can mediate dimerization and sequence-specific DNA binding.
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