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Related Concept Videos

Reporter Genes02:11

Reporter Genes

Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
Commonly used reporter...
From DNA to Protein03:06

From DNA to Protein

The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
What is Gene Expression?01:36

What is Gene Expression?

A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then processed and...
What is Gene Expression?01:42

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
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What is Gene Expression?01:42

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Genetic Information Flows from DNA to RNA to Protein
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The Central Dogma01:25

The Central Dogma

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Sample Preparation and Analysis of RNASeq-based Gene Expression Data from Zebrafish
11:42

Sample Preparation and Analysis of RNASeq-based Gene Expression Data from Zebrafish

Published on: October 27, 2017

Gene symbol precision.

Barbara Bennani-Baiti1, Idriss M Bennani-Baiti

  • 1Department for Medicinal Chemistry, University of Vienna, A-1090 Vienna, Austria.

Gene
|October 25, 2011
PubMed
Summary
This summary is machine-generated.

Gene databases sometimes misattribute scientific literature due to overlapping gene aliases. Using Entrez gene numbers in publications can ensure accurate gene identification and species tracking.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Gene databases like NCBI occasionally misassign literature references to genes or proteins.
  • These errors often stem from shared gene aliases between distinct genes, causing confusion, especially when gene products share biological functions or regulatory pathways.

Purpose of the Study:

  • To highlight the problem of erroneous gene and protein literature assignments in major databases.
  • To propose a standardized solution for precise gene identification in scientific publications.

Main Methods:

  • Analysis of gene alias overlaps across various research fields.
  • Presentation of specific examples illustrating the confusion caused by erroneous database entries.

Main Results:

  • Identified instances of misattributed literature in diverse areas such as apoptosis, signal transduction (Notch, Wnt, small G proteins), and gene regulation.
  • Demonstrated how overlapping gene aliases complicate accurate data retrieval and interpretation.

Conclusions:

  • The current system of gene identification in databases is prone to errors due to shared aliases.
  • Recommending the inclusion of unique Entrez gene numbers in submitted manuscripts is crucial for precise gene and species identification, thereby improving data integrity.