Related Experiment Videos
Does autonomic dysfunction exist in postmenopausal osteoporosis?
Aliye Tosun1, Mehmet Tolga Doğru, Gülümser Aydn
1Department of Physical Medicine and Rehabilitation, Ankara Atatürk Education and Research Hospital, Ankara, Turkey.
American Journal of Physical Medicine & Rehabilitation
|October 25, 2011
Summary
Osteoporosis patients exhibit autonomic dysfunction, with altered sympathetic and parasympathetic activity affecting cardiac function. This study highlights potential links between bone health and the nervous system.
Area of Science:
- Endocrinology
- Neurology
- Cardiology
Background:
- Osteoporosis is a prevalent skeletal disorder primarily affecting postmenopausal women.
- Autonomic nervous system (ANS) dysfunction can impact various physiological systems, including cardiovascular health.
- The relationship between osteoporosis and ANS function remains incompletely understood.
Purpose of the Study:
- To investigate the presence and characteristics of autonomic dysfunction in postmenopausal women with osteoporosis.
- To evaluate potential alterations in autonomic nervous system activity in osteoporosis patients compared to healthy controls.
Main Methods:
- A prospective controlled trial involving 16 postmenopausal women with osteoporosis and 10 age-matched controls.
- Assessment of autonomic function using heart rate variability (HRV) parameters and sympathetic skin responses (SSRs).
- Classification of participants into osteoporosis and control groups based on bone mineral density measurements.
Main Results:
- Patients with osteoporosis showed significantly prolonged SSR latencies in both hands compared to controls.
- A significant decrease in SSR amplitude was observed in the right hands and both feet of the osteoporosis group.
- Osteoporosis patients exhibited a significantly decreased 24-hour high-frequency HRV value and an increased low-/high-frequency ratio, indicating altered cardiac autonomic regulation.
Conclusions:
- Autonomic dysfunction, characterized by increased sympathetic and decreased parasympathetic activity, is likely present in patients with osteoporosis.
- Cardiac functions in individuals with osteoporosis may be compromised due to associated autonomic dysfunction.
- These findings suggest a potential link between skeletal health and autonomic nervous system regulation.
Related Concept Videos
01:28Menopause
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:40Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
01:18Disorders of the Autonomic Nervous System
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's phenomenon, is a...
Raynaud's disease, also known as Raynaud's phenomenon, is a...
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
01:31Osteoclasts in Bone Remodeling
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...