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Updated: May 28, 2026

Tracking Mouse Bone Marrow Monocytes In Vivo
Published on: February 27, 2015
Bone marrow and the control of immunity
Ende Zhao1, Huanbin Xu, Lin Wang
1Department of Surgery, University of Michigan School of Medicine, 1150 W. Medical Center Dr., Ann Arbor, MI 48109-0669, USA.
Abstract:
Bone marrow is thought to be a primary hematopoietic organ. However, accumulated evidences demonstrate that active function and trafficking of immune cells, including regulatory T cells, conventional T cells, B cells, dendritic cells, natural killer T (NKT) cells, neutrophils, myeloid-derived suppressor cells and mesenchymal stem cells, are observed in the bone marrow. Furthermore, bone marrow is a predetermined metastatic location for multiple human tumors. In this review, we discuss the immune network in the bone marrow. We suggest that bone marrow is an immune regulatory organ capable of fine tuning immunity and may be a potential therapeutic target for immunotherapy and immune vaccination.
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