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Related Experiment Video

Updated: May 28, 2026

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

Sonic hedgehog signaling during adrenal development.

Ed Laufer¹, Dörthe Kesper, Andrea Vortkamp

¹Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA. elaufer@columbia.edu

Molecular and Cellular Endocrinology

|October 25, 2011

Summary

This summary is machine-generated.

Sonic hedgehog (Shh) signaling is crucial for adrenal development, promoting growth of the adrenal cortex and capsule. Shh pathway activation in mouse models reveals its role in maintaining adrenocortical stem and progenitor cells.

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Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands

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Published on: October 2, 2018

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Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

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Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands

Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands

Published on: October 2, 2018

Area of Science:

Endocrinology
Developmental Biology
Molecular Biology

Background:

Sonic hedgehog (Shh) signaling has long been suspected to influence adrenal gland development.
Recent studies have focused on Shh pathway gene expression and function in the adrenal cortex, primarily using mouse models.

Purpose of the Study:

To elucidate the role of Sonic hedgehog (Shh) signaling in adrenal development.
To define the contribution of Shh signaling to adrenocortical cell lineages and stem/progenitor cell populations.

Main Methods:

Utilized mouse models to study Shh pathway gene expression and function in the adrenal cortex.
Employed molecular genetic tools to trace cell lineages descended from Shh signaling and receiving cells.

Main Results:

Shh signals from partially differentiated cortical cells are received by capsular mesenchymal cells.
Shh signaling is essential for adrenal capsule and cortex growth, but not for zonation or steroidogenic differentiation.
Both capsular and cortical cells influenced by Shh exhibit properties of adrenocortical stem/progenitor cells.

Conclusions:

Shh signaling is a key regulator of adrenal gland growth and maintenance.
The Shh pathway plays a significant role in the biology of adrenocortical stem and progenitor cells.
These findings integrate recent observations into the broader context of adrenal development and stem cell biology.