Related Experiment Video
Updated: May 28, 2026
Direct Mouse Trauma/Burn Model of Heterotopic Ossification
Published on: August 6, 2015
Heterotopic ossification associated with recombinant human bone morphogenetic protein-2 (infuse) in posterolateral
Christopher L Anderson1, M Camden Whitaker
1Department of Surgery, Section of Orthopaedics, The University of Kansas School of Medicine-Wichita, Wichita, KS 67214, USA. canderson2@kumc.edu
Study Design:
A case of heterotopic ossification in the lumbar spine associated with the off-label use of recombinant human bone morphogenetic protein-2 (rhBMP-2) is reported.
Objective:
To highlight a previously unreported complication of rhBMP-2 use and to review the literature pertinent to the topic.
Summary Of Background Data:
There is no report in the literature regarding a large mass of rhBMP-2-associated heterotopic ossification surrounding the paraspinal musculature.
Methods:
The clinical and radiographical features of this complication and treatment course are presented.
Results:
The surgical excision of heterotopic ossification and removal of symptomatic instrumentation have resulted in the patient remaining asymptomatic at 1 year of follow-up examination.
Conclusion:
The reported case adds to the literature of off-label use of rhBMP-2 and the potential for the formation of heterotopic ossification with its use.
