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Hematologic disorders and ischemic stroke. A selective review.

R G Hart1, M C Kanter

  • 1Department of Medicine (Neurology), University of Texas Health Science Center, San Antonio 78284.

Stroke
|August 1, 1990
PubMed
Summary
This summary is machine-generated.

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Hematologic disorders are linked to ischemic stroke. Screening for inherited and acquired prothrombotic conditions is crucial, especially in young patients or those with recurrent strokes, to identify underrecognized causes.

Area of Science:

  • Hematology
  • Neurology
  • Vascular Medicine

Background:

  • Ischemic stroke is associated with over a dozen primary hematologic disorders.
  • Inherited deficiencies (antithrombin III, protein C, S) and acquired states (antiphospholipid antibodies, lupus anticoagulants) are implicated.
  • Disorders of formed blood elements like polycythemia vera and sickle cell anemia are major contributors.

Purpose of the Study:

  • To highlight the association between hematologic disorders and ischemic stroke.
  • To emphasize the need for comprehensive screening for prothrombotic entities.
  • To underscore the underrecognized contribution of prothrombotic diatheses to stroke.

Main Methods:

  • Review of case reports and identified acquired states.
  • Discussion of diagnostic requirements for inherited deficiencies (functional and antigenic assays).

Related Experiment Videos

  • Recommendation for step-wise screening in specific patient populations.

    • Main Results:

    • Antiphospholipid antibodies and lupus anticoagulants are frequent acquired causes.
    • Polycythemia vera, sickle cell anemia, sickle-C disease, and essential thrombocythemia are key formed element disorders.
    • Acquired abnormalities in platelets, coagulation, and fibrinolysis may synergize with other mechanisms but are ill-defined.

    Conclusions:

    • Specialized screening for prothrombotic conditions is recommended for stroke patients with uncertain causes, prior thrombosis, family history, or recurrent strokes.
    • The role of prothrombotic diatheses in stroke is likely underrecognized.
    • Further investigation into these associations is warranted.