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Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
Published on: September 6, 2019
Three-component, one-pot sequential synthesis of glyco-hydantoin conjugates
Maria Cristina Bellucci1, Alessandra Ghilardi, Alessandro Volonterio
1Dipartimento di Chimica Agroalimentare, Università degli Studi di Milano, via Celoria 2, 20133 Milano, Italy.
Abstract:
The development of new methods for linking sugars to heterocycles and peptides is an attractive area of research because glyco-conjugates play important roles in biology and medicine and are indispensable tools for probing several processes. Herein we report a one-pot, three-component sequential procedure for the synthesis of a novel class of glyco-conjugates, i.e. glyco-hydantoin conjugates, in high yields and very mild conditions, using readily accessible starting materials. We also demonstrated that some of the glyco-hydantoin conjugates obtained are synthons for the preparation of a novel class of glyco-pseudopeptides in which the amino acid is tethered to the sugar through the hydantoin ring.
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