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Radiation recall myositis in pediatric Ewing sarcoma
Jona Hattangadi1, Brittany Esty, Brian Winey
1Harvard Radiation Oncology Program, Boston, Massachusetts 02215, USA. jhattangadi@partners.org
Pediatric Blood & Cancer
|October 25, 2011
Summary
Radiation recall is a rare inflammatory reaction. This study highlights radiation recall myositis in pediatric Ewing sarcoma patients, identified via MRI muscle edema after proton radiotherapy and chemotherapy.
Area of Science:
- Oncology
- Radiotherapy
- Pediatric Cancer
Background:
- Radiation recall is a rare phenomenon involving inflammation in previously irradiated areas.
- It is typically triggered by systemic agents and often affects the skin.
- Radiation recall myositis without skin involvement is exceptionally rare.
Observation:
- Two pediatric patients with Ewing sarcoma experienced radiation recall.
- These patients underwent sequential proton radiotherapy and chemotherapy.
- Magnetic resonance imaging (MRI) revealed muscle edema within prior radiation fields.
Findings:
- The cases demonstrate radiation recall myositis in pediatric patients.
- The findings confirm that radiation recall can manifest as muscle inflammation.
- MRI is a valuable tool for diagnosing radiation recall myositis.
Implications:
- This study expands the understanding of radiation recall presentations.
- It highlights the importance of considering radiation recall myositis in pediatric cancer patients.
- Further research is needed to elucidate the mechanisms and management of radiation recall.
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