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Updated: May 28, 2026
05:51
Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness
Published on: May 3, 2018
Arterial stiffness evaluation in HIV-positive patients: a multicenter matched control study
Giovanna Ferraioli1, Carmine Tinelli, Paolo Maggi
1Ultrasound Unit, Infectious Diseases Department, IRCCS Fondazione Policlinico San Matteo-University of Pavia, Italy. giovanna.ferraioli@unipv.it
AJR. American Journal of Roentgenology
|October 25, 2011
Summary
HIV-infected individuals exhibit reduced arterial compliance compared to controls, indicating potential subclinical atherosclerosis. This study assessed carotid artery stiffness in HIV patients versus matched uninfected individuals.
Area of Science:
- Cardiovascular Medicine
- Infectious Diseases
- Biomedical Engineering
Background:
- Arterial stiffness is an emerging predictor of cardiovascular disease (CVD) risk.
- HIV infection is associated with an increased risk of CVD.
- Carotid artery stiffness can be evaluated using automated echo-tracking ultrasound systems.
Purpose of the Study:
- To compare carotid artery stiffness parameters between HIV-infected individuals and matched HIV-uninfected controls.
- To identify potential differences in arterial stiffness in HIV-infected subjects without known CVD or plaques.
Main Methods:
- Fifty-four HIV-infected patients and 54 matched HIV-uninfected controls were studied.
- Carotid artery stiffness parameters and intima-media thickness were measured using ultrasound.
- Statistical analysis included Mann-Whitney U test, chi-square, and correlation coefficients.
Main Results:
- HIV-infected subjects demonstrated significantly lower arterial compliance (p = 0.0009) compared to controls.
- Other arterial stiffness parameters were similar between the groups.
- Arterial stiffness parameters correlated with age in both groups.
Conclusions:
- HIV-infected individuals have impaired carotid artery distensibility.
- Reduced arterial compliance in HIV may contribute to subclinical atherosclerosis.
- These findings highlight the importance of monitoring cardiovascular risk in HIV patients.
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