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Localization of renin substrate in fetoplacental tissue
K P Metsärinne1, F Pekonen, F Y Fyhrquist
1Minerva Foundation Institute for Medical Research, Helsinki, Finland.
Acta Endocrinologica
|July 1, 1990
Abstract:
Specific polyclonal rabbit anti-human renin substrate-antibodies were used in order to study the distribution of renin substrate immunoreactivity in human fetal and placental tissue. Renin substrate was immunohistochemically detected in human decidua and placenta, as well as in 19 weeks old human fetal liver and kidney. The presence of renin substrate in fetoplacental tissue supports the concept of a locally functioning renin-angiotensin system.