Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

Cerebellum: Anatomical Regions

Cerebellum: Anatomical Regions

The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...

Functional Brain Systems: Limbic System

Functional Brain Systems: Limbic System

The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...

Role of Cerebellum and Prefrontal Cortex in Memory

Role of Cerebellum and Prefrontal Cortex in Memory

The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the cerebellum's...

Cerebrum: Anatomical Overview II

Cerebrum: Anatomical Overview II

Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...

Cerebral Hemispheres

Cerebral Hemispheres

The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Iron-induced Oxidative Stress and Anxiety-like Behavior in Wistar Rats Following Systemic Iron Administration.

Biological trace element research·2025

Same author

SELENOPROTEIN T deficiency alters projection neuron migration during corticogenesis in mice.

Neuroscience·2025

Same author

Prolonging lung cancer response to EGFR inhibition by targeting the selective advantage of resistant cells.

Nature communications·2025

Same author

Sub-Chronic 30 mg/kg Iron Treatment Induces Spatial Cognition Impairment and Brain Oxidative Stress in Wistar Rats.

Biological trace element research·2025

Same author

Development and validation of a performance assessment checklist for insertion of an intra-uterine device (IUD).

Ginekologia polska·2023

Same author

Excessive self-grooming, gene dysregulation and imbalance between the striosome and matrix compartments in the striatum of <i>Shank3</i> mutant mice.

Frontiers in molecular neuroscience·2023

Search research articles

Related Experiment Video

Updated: May 28, 2026

Horizontal Hippocampal Slices of the Mouse Brain

Horizontal Hippocampal Slices of the Mouse Brain

Published on: September 22, 2020

Cerebellum shapes hippocampal spatial code.

Christelle Rochefort¹, Arnaud Arabo, Marion André

¹Neurobiologie des Processus Adaptatifs (UMR 7102), Navigation, Memory, and Aging (ENMVI) Team, Université Pierre et Marie Curie-Centre National de la Recherche Scientifique (CNRS), F-75005 Paris, France.

Science (New York, N.Y.)

|October 25, 2011

Summary

This summary is machine-generated.

The cerebellum

More Related Videos

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

Related Experiment Videos

Last Updated: May 28, 2026

Horizontal Hippocampal Slices of the Mouse Brain

Horizontal Hippocampal Slices of the Mouse Brain

Published on: September 22, 2020

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

Area of Science:

Neuroscience
Cerebellar Function
Spatial Navigation

Background:

Spatial representation relies on integrating multimodal sensory information across brain networks.
The cerebellum's role in spatial navigation and its underlying plasticity mechanisms remain incompletely understood.

Purpose of the Study:

To investigate the specific role of cerebellar protein kinase C (PKC)-dependent plasticity in spatial navigation.
To determine how disruption of PKC signaling in the cerebellum affects hippocampal place cell activity and navigation behaviors.

Main Methods:

Recorded hippocampal place cell activity in transgenic L7PKCI mice with disrupted cerebellar PKC-dependent plasticity.
Assessed navigation capabilities using a path integration task.

Main Results:

Impaired place cell properties were observed exclusively when mice relied on self-motion cues.
Transgenic mice exhibited deficits in path integration, indicating impaired navigation.

Conclusions:

Cerebellar PKC-dependent plasticity is crucial for processing self-motion signals.
These cerebellar mechanisms are essential for shaping hippocampal spatial representations and enabling effective navigation.