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A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice

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Steroid-induced central serous retinopathy.

Samidh P Shah¹, Chetna K Desai, Mira K Desai

¹Department of Pharmacology, B. J. Medical College, Ahmedabad, Gujarat, India.

Indian Journal of Pharmacology

|October 25, 2011

Summary

A young man developed central serous retinopathy (CSR) after taking prednisolone for facial palsy. Vision improved after discontinuing the steroid, confirming a drug reaction and highlighting the need for awareness.

Keywords:

Adverse drug reaction central serous retinopathy corticosteroids

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Area of Science:

Ophthalmology
Pharmacology

Background:

Facial palsy is often treated with corticosteroids like prednisolone.
Corticosteroids are known to have various adverse drug reactions (ADRs).
Central Serous Retinopathy (CSR) is a condition affecting vision.

Purpose of the Study:

To report a case of steroid-induced central serous retinopathy (CSR).
To highlight the potential adverse drug reaction (ADR) of corticosteroid therapy.
To emphasize the importance of recognizing and reporting this ADR for patient management.

Main Methods:

A case study of a 24-year-old male patient prescribed 60 mg/day of prednisolone for left-sided facial palsy.
Ophthalmic examination including fluorescein angiography of the right eye.
Monitoring of patient's condition after gradual withdrawal of prednisolone (dechallenge).

Main Results:

The patient developed visual disturbances (black spots) in the right eye after three days of prednisolone therapy.
Fluorescein angiography confirmed central serous retinopathy (CSR) in the affected eye.
Symptoms resolved within a week following the gradual discontinuation of prednisolone.

Conclusions:

The case confirms a link between prednisolone use and the development of central serous retinopathy (CSR).
Steroid-induced CSR is a significant adverse drug reaction (ADR) that can lead to vision loss if recurrent.
Increased awareness and reporting of this ADR are crucial for effective patient management and prevention of complications.