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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

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Related Experiment Video

Updated: May 28, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

[Laboratory animal; allergy; asthma].

M Corradi1, C Romano, A Mutti

  • 1Dipartimento di Clinica Medica, Nefrologia e Scienze della Prevenzione, Università degli Studi di Parma. massimo.corradi@unipr.it

La Medicina Del Lavoro
|October 26, 2011
PubMed
Summary

Laboratory animal allergy (LAA) affects 30% of exposed individuals, often developing within three years. Early detection and workplace controls are key to managing LAA and preventing occupational asthma.

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Area of Science:

  • Occupational Health
  • Allergology
  • Immunology

Context:

  • Laboratory animal allergy (LAA) is a significant occupational health concern.
  • Exposure to allergens from rodents, rabbits, guinea pigs, and dogs can trigger LAA.
  • Individuals with pre-existing allergies are at higher risk.

Purpose:

  • To summarize the etiology, symptoms, and risk factors of laboratory animal allergy.
  • To outline preventive strategies and medical surveillance for LAA.
  • To emphasize early detection and worker counseling in occupational health programs.

Summary:

  • LAA develops in susceptible individuals upon exposure to animal allergens (urine, fur, saliva), with symptoms typically appearing within three years.
  • Common symptoms include rhinitis and conjunctivitis, but asthma and skin reactions can also occur.
  • Allergen levels increase significantly during animal handling and cage cleaning, necessitating environmental controls and protective measures.

Impact:

  • Highlights the prevalence (30%) and potential for developing occupational asthma.
  • Stresses the importance of pre-placement evaluations and ongoing medical surveillance for early LAA detection.
  • Informs the development of comprehensive occupational health strategies to mitigate LAA risks in laboratory settings.