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Related Experiment Videos

Gastrointestinal hormones: from basic science to a clinical perspective.

A Shulkes1

  • 1Department of Surgery, University of Melbourne, Austin Hospital, Victoria, Australia.

The Australian and New Zealand Journal of Surgery
|August 1, 1990
PubMed
Summary

Regulatory peptides, not just gastrointestinal hormones, control digestion and gut function. Advances in understanding these peptides are leading to new therapies for various conditions, including tumors and digestive disorders.

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Area of Science:

  • Gastroenterology
  • Endocrinology
  • Pharmacology

Background:

  • The gastrointestinal tract functions as the body's largest endocrine organ, producing regulatory peptides.
  • These peptides are delivered via circulation, neural, and paracrine routes, influencing digestion, absorption, secretion, motility, and growth.
  • Understanding individual peptide functions was challenging due to their concerted action.

Purpose of the Study:

  • To explore the role of regulatory peptides in gastrointestinal physiology.
  • To highlight advancements in understanding peptide functions through agonists and antagonists.
  • To discuss the therapeutic potential arising from this research.

Main Methods:

  • Development and application of specific regulatory peptide agonists and antagonists.

Related Experiment Videos

  • Clinical trials and therapeutic applications of identified peptides and their derivatives.
  • Investigating the trophic effects of peptides on cell proliferation, such as gastrin antagonists on colon carcinoma.

    • Main Results:

    • Significant progress in understanding gastrointestinal peptide physiology.
    • Identification of therapeutic applications for peptides like somatostatin derivatives (octreotide) for tumors and other conditions.
    • Development of new agents, such as motilin receptor agonists for impaired gastric emptying.
    • Demonstration of clinical significance of peptide trophic effects, e.g., gastrin's role in cell proliferation.

    Conclusions:

    • Specific peptide agonists and antagonists have greatly advanced the understanding of gastrointestinal regulatory peptides.
    • This research is paving the way for novel therapeutic strategies for a range of gastrointestinal and endocrine disorders.
    • The discovery of more mammalian regulatory peptides is anticipated, further expanding the field.