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Related Concept Videos

Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...

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Related Experiment Video

Updated: May 28, 2026

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

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Published on: November 3, 2023

A transient improvement in renal function occurs after ischemic stroke.

Dominik Georg Haider1, Julia Ferrari, Friedrich Mittermayer

  • 1Division of Nephrology and Dialysis, Department of Internal Medicine 3, Medical University of Vienna, Vienna, Austria. dominik.haider@meduniwien.ac.at

Renal Failure
|October 26, 2011
PubMed
Summary

Acute ischemic stroke can temporarily improve kidney function in patients with pre-existing kidney impairment, diabetes, or heart failure. This effect suggests a central regulation mechanism influencing renal function after a stroke.

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Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
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Induction of Ischemic Stroke and Ischemia-reperfusion in Mice Using the Middle Artery Occlusion Technique and Visualization of Infarct Area
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Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration
12:27

Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration

Published on: June 7, 2014

Area of Science:

  • Nephrology
  • Neurology
  • Cardiology

Background:

  • Neurohumoral influences on kidney function are recognized.
  • Stroke alters the regulation of the renin-angiotensin system and sympathetic nerve activity.

Purpose of the Study:

  • To investigate the impact of acute ischemic stroke on renal function.
  • To analyze changes in serum creatinine levels post-stroke.

Main Methods:

  • Serum creatinine was monitored for one week in 220 patients following acute ischemic stroke.
  • Patients were categorized based on pre-existing conditions like chronic kidney disease, diabetes, and heart failure.

Main Results:

  • Renal function transiently improved in patients with chronic kidney disease (serum creatinine >1.2 mg/dL), diabetes, and heart failure post-stroke.
  • A significant decrease in serum creatinine was observed in these subgroups, indicating temporary renal function enhancement.
  • No significant changes in serum creatinine were noted in patients with normal renal function at admission.

Conclusions:

  • Acute ischemic stroke can lead to intermittent improvements in impaired kidney function.
  • The underlying mechanism for this renal function enhancement may involve central regulatory pathways.