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Related Experiment Video

Updated: May 28, 2026

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

Malaria drug resistance: new observations and developments.

Juliana M Sá¹, Jason L Chong, Thomas E Wellems

¹Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

Essays in Biochemistry

|October 26, 2011

Summary

Drug resistance in microorganisms, particularly antimalarial resistance, emerged early and has had severe impacts. Understanding the molecular genetics of resistance is crucial for developing new treatments.

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Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria

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Published on: November 10, 2015

Area of Science:

Pharmacology
Infectious Diseases
Molecular Genetics

Background:

Widespread drug resistance in microorganisms emerged in the 20th century, impacting infectious disease treatment.
Antimalarial resistance is a significant historical example, driven by the use of natural and synthetic drugs.
Early antimalarial drugs like quinine and synthetic analogs faced resistance challenges.

Purpose of the Study:

To provide a synopsis of antimalarial drug development, from natural remedies to synthetic compounds.
To review the historical contributions of antimalarial efficacy studies to clinical pharmacology.
To discuss emerging molecular genetic insights into drug resistance, particularly artemisinin resistance.

Main Methods:

Historical review of antimalarial drug development and resistance.
Analysis of early clinical pharmacology studies on antimalarial efficacy.
Examination of recent molecular genetic findings related to drug resistance.

Main Results:

Early documentation of atebrine-resistant malaria predates the widespread use of chloroquine and amodiaquine.
Natural remedies (qinghaosu, cinchona bark) and synthetic drugs have shaped antimalarial treatment.
Delayed parasite clearance with artemisinin derivatives is a growing concern in Southeast Asia.

Conclusions:

The history of antimalarial drugs is marked by the continuous evolution of parasite resistance.
Understanding the molecular basis of resistance is vital for combating malaria.
Ongoing research into drug resistance mechanisms is essential for future therapeutic strategies.