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Published on: July 20, 2016
Hepcidin expression in patients with acute leukaemia
Pan-Pan Cheng1, Zhen-Zhen Sun, Fang Jiang
1Department of Clinical Laboratory, Affiliated Hospital of Jining Medical College, Jining, Shandong, China.
European Journal of Clinical Investigation
|October 26, 2011
Summary
Hepcidin levels in acute leukemia (AL) patients initially increase with iron stores and inflammation, then decrease during remission. Erythropoiesis significantly influences hepcidin regulation in AL.
Area of Science:
- Hematology
- Iron Metabolism
- Oncology
Background:
- Hepcidin is crucial for iron homeostasis, influenced by iron stores, erythropoiesis, inflammation, and hypoxia.
- Limited data exists on hepcidin expression in acute leukemia (AL).
Purpose of the Study:
- To investigate hepcidin expression and its regulators in patients with acute leukemia.
Main Methods:
- Studied 32 acute leukemia patients (FAB criteria).
- Evaluated serum hepcidin, erythropoietin (EPO), interleukin-6 (IL-6), hematological parameters, and iron stores.
Main Results:
- Hepcidin was elevated at AL onset with increased iron storage and suppressed erythropoiesis.
- Hepcidin decreased during AL remission, with elevated soluble transferrin receptor (sTfR).
- Significant correlations found between hepcidin and iron stores, IL-6, and inverse correlations with erythropoietic markers.
Conclusions:
- Hepcidin production in AL is modulated by iron stores, inflammation, and erythropoiesis.
- Erythropoietic activity appears to be the primary regulator of hepcidin expression in AL.
