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The function of cyclic-adenosine monophosphate responsive element-binding protein in hematologic malignancies
Bryan Mitton1, Er-Chieh Cho, Grace I Aldana-Masangkay
1Division of Pediatric Hematology/Oncology, Mattel Children's Hospital UCLA, Los Angeles, CA 90095-1752, USA.
Leukemia & Lymphoma
|October 26, 2011
Summary
Understanding cyclic-adenosine monophosphate (cAMP) responsive element-binding protein (CREB) signaling is key to developing new leukemia and lymphoma treatments. CREB, a proto-oncogene, is a potential therapeutic target due to its role in cancer cell proliferation and survival.
Area of Science:
- Hematology
- Molecular Biology
- Oncology
Background:
- Leukemias and lymphomas involve uncontrolled cell cycle progression, proliferation, and survival.
- Cyclic-adenosine monophosphate (cAMP) responsive element-binding protein (CREB) integrates cytoplasmic kinase signals.
- CREB controls transcription of genes vital for cellular proliferation and survival.
Purpose of the Study:
- To review the function and regulation of CREB in normal and aberrant hematopoiesis.
- To highlight CREB's role as a proto-oncogene in leukemogenesis.
- To discuss CREB as a potential therapeutic target for leukemia.
Main Methods:
- Literature review of CREB function in hematopoiesis.
- Analysis of evidence implicating CREB in oncogenesis.
- Examination of CREB dysregulation in hematological malignancies.
Main Results:
- CREB is a critical integrator of signaling pathways.
- Translocations and dysregulation of CREB are associated with oncogenesis.
- CREB plays a role in controlling cell proliferation and survival.
Conclusions:
- Understanding CREB signaling is crucial for novel leukemia and lymphoma therapies.
- CREB's proto-oncogenic activity makes it a viable therapeutic target.
- Targeting CREB may offer new treatment strategies for hematological cancers.
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