HSP22 and its role in human neurological disease
Xiaomei Guan1, Chao Tu, Mengjun Li
1Department of Neurology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Abstract:
HSP22 (heat shock protein 22), belonging to the superfamily of small heat shock proteins, which has a molecular mass of 21.6 KD and is able to exist in the form of monomer, has multiple functions including molecular chaperones, apoptosis and anti-apoptosis, lifespan extension, antioxidation and so on. In recent years, studies show that HSP22 plays a crucial role in many neurological diseases, such as hereditary nerve endings disease, Alzheimer disease and Charco-Marie-Tooth. This review explores the progress in HSP22 and its involvement in human neurological disease.
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