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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

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A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
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A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Osteoporosis in men: update 2011.

Denise L Orwig1, Nancy Chiles, Mark Jones

  • 1Department of Epidemiology and Public Health, School of Medicine, University of Maryland, 660 West Redwood Street, Suite 200, Baltimore, MD 21201, USA. dorwig@epi.umaryland.edu

Rheumatic Diseases Clinics of North America
|October 26, 2011
PubMed
Summary
This summary is machine-generated.

Recent reviews cover osteoporosis in men, focusing on bone mineral density screening, fracture risk assessment, secondary causes, lab testing, and new treatments. This research synthesizes current knowledge on male osteoporosis prevalence and management.

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Area of Science:

  • Endocrinology
  • Geriatrics
  • Orthopedics

Background:

  • Osteoporosis is a significant health concern in aging men.
  • Recent literature reviews have synthesized key findings and recommendations for male osteoporosis.

Purpose of the Study:

  • To summarize recent advancements in the understanding and management of osteoporosis in men.
  • To highlight updated screening, diagnosis, and treatment guidelines.

Main Methods:

  • Review of recently published literature on male osteoporosis.
  • Synthesis of recommendations for bone mineral density (BMD) measurement.
  • Evaluation of fracture risk assessment tools and secondary causes.

Main Results:

  • Established screening recommendations for BMD in older men.
  • Utilization of the World Health Organization's Fracture Risk Assessment Tool for fracture prediction.
  • Identification of secondary causes and relevant laboratory tests.
  • Overview of emerging treatments for increasing BMD and reducing fracture risk.
  • Presentation of new data on the prevalence of low BMD and osteoporosis in men.

Conclusions:

  • Current reviews provide a comprehensive update on osteoporosis in men.
  • Guidelines emphasize screening, risk assessment, and tailored treatment strategies.
  • Further research continues to refine the diagnosis and management of osteoporosis in the male population.