Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
What is the Skeletal System?01:02

What is the Skeletal System?

Overview
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiomic profiling of responses to clinical and novel bisphosphonates reveals extraskeletal effects on ageing related signatures.

Signal transduction and targeted therapy·2026
Same author

Goal-directed osteoporosis treatment: are bone mineral density targets valid?

The lancet. Diabetes & endocrinology·2026
Same author

Cost-savings from fracture prevention with zoledronate in randomised controlled trials.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same author

Management of postmenopausal osteoporosis.

Endocrine reviews·2026
Same author

Skeletal fluorosis from excessive tea drinking.

Internal medicine journal·2026
Same author

Decreased Nonvertebral Fracture Incidence with Zoledronate Use For >3 Years: Post Hoc Analysis of an RCT.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026

Related Experiment Video

Updated: May 28, 2026

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

Paget's disease of bone.

Tim Cundy1, Ian R Reid

  • 1Department of Medicine, Faculty of Medical & Health Sciences, University of Auckland, New Zealand. t.cundy@auckland.ac.nz

Clinical Biochemistry
|October 26, 2011
PubMed
Summary

Recent research indicates Paget

Area of Science:

  • Bone Metabolism and Genetics
  • Rheumatology and Endocrinology

Background:

  • Paget's disease of bone is a chronic condition affecting bone remodeling.
  • Understanding its etiology and effective management is crucial.

Purpose of the Study:

  • To review recent advancements in the understanding of Paget's disease causation.
  • To summarize current approaches to the management of Paget's disease.

Main Methods:

  • Literature review of recent publications.
  • Focus on etiological factors and biochemical markers for diagnosis and treatment monitoring.

Main Results:

  • Paget's disease prevalence and severity appear to be decreasing, suggesting environmental influences.
  • Strong genetic predisposition is evident, particularly linked to the SQSTM1 gene and other loci.

Related Experiment Videos

Last Updated: May 28, 2026

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

  • Plasma alkaline phosphatase (ALP) is a common marker, but plasma procollagen-1 N-peptide (PINP) shows better performance.
  • Potent bisphosphonate therapy typically achieves long-term remission.

    • Conclusions:

    • Both genetic and environmental factors contribute to the development of Paget's disease.
    • Bisphosphonate treatment offers effective and sustained suppression of the disease.