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A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
Large cell neuroendocrine carcinoma of the head and neck
Kimihide Kusafuka1, Alfio Ferlito, James S Lewis
1Pathology Division, Shizuoka Cancer Center Hospital and Research Institute, Shizuoka, Japan.
Oral Oncology
|October 26, 2011
Abstract:
Large cell neuroendocrine carcinoma is a poorly differentiated neuroendocrine carcinoma that usually occurs in the lung. Although rare in the head and neck, salivary and mucosal subtypes are recognized. This article describes their characteristic light microscopic and immunohistochemical features and highlights the importance of accurate diagnosis, management and prognostic implications.