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Related Experiment Video

Updated: May 28, 2026

Fluorescence and Bioluminescence Imaging of Subcellular Ca2+ in Aged Hippocampal Neurons

Fluorescence and Bioluminescence Imaging of Subcellular Ca²⁺ in Aged Hippocampal Neurons

Published on: December 1, 2015

New neurons in an aged brain.

Star W Lee¹, Gregory D Clemenson, Fred H Gage

¹Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Behavioural Brain Research

|October 26, 2011

Summary

This summary is machine-generated.

Aging significantly reduces adult hippocampal neurogenesis, impacting neural progenitor cells and the neurogenic niche. This decline may affect cognitive function, necessitating new research approaches.

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Area of Science:

Neuroscience
Cell Biology
Aging Research

Background:

Adult hippocampal neurogenesis is a continuous process throughout life, crucial for synaptic plasticity.
Neurogenesis rate declines with age, marked by reduced progenitor cell proliferation, differentiation, and survival.
Age-related intrinsic changes in neural progenitor cells and the neurogenic niche microenvironment contribute to this decline.

Purpose of the Study:

To review age-related changes in adult hippocampal neurogenesis.
To discuss alterations in neural progenitor cells and the neurogenic niche in aging.
To examine the link between neurogenesis and cognitive function in aged animals and highlight the need for specific behavioral tasks.

Main Methods:

Review of existing literature on adult hippocampal neurogenesis and aging.
Analysis of studies on intrinsic properties of neural progenitor cells (gene transcription, telomerase activity).
Examination of age-related changes in neurogenic niche cells (astrocytes, microglia, endothelial cells).
Discussion of behavioral paradigms for assessing hippocampus-dependent cognition.

Main Results:

Older animals exhibit significantly reduced neurogenesis compared to younger ones.
Intrinsic cellular properties and niche cell alterations contribute to age-related neurogenesis decline.
Correlation between decreased neurogenesis and cognitive impairment is common, but not universal, in aged mice.

Conclusions:

Aging profoundly impacts adult hippocampal neurogenesis through cellular and environmental changes.
The neurogenic niche undergoes significant age-related alterations affecting neural progenitor cell function.
Further development of neurogenesis-dependent behavioral tasks is crucial for understanding cognitive aging.