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Updated: May 28, 2026
10:49
Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
Typhlitis in acute childhood leukemia.
Esma Altınel1, Nese Yarali, Pamir Isık
1Department of Pediatric Hematology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey.
Summary
Typhlitis occurred in 4.5% of children with acute leukemia, with a 20% mortality rate. Early medical intervention is crucial for improving outcomes in these pediatric oncology patients.
Area of Science:
- Pediatric Oncology
- Hematology
- Gastroenterology
Background:
- Typhlitis, also known as neutropenic enterocolitis, is a serious complication in pediatric patients undergoing chemotherapy for acute leukemia.
- Understanding the incidence, clinical presentation, and outcomes of typhlitis is vital for effective management.
Purpose of the Study:
- To review the experience with typhlitis in children treated for acute leukemia.
- To analyze the demographics, symptoms, and outcomes of typhlitis in this patient population.
Main Methods:
- Retrospective review of medical records of children with acute leukemia and typhlitis from 2006 to 2009.
- Data collected included demographics, symptoms, microbiological findings, and imaging results.
Main Results:
- Ten episodes of typhlitis (4.5%) occurred in 75 children with acute leukemia during 221 periods of severe neutropenia.
- Cumulative risk was 7.4% for acute lymphoblastic leukemia (ALL) and 28.5% for acute myeloid leukemia (AML).
- Common symptoms included abdominal pain, tenderness, and fever; mortality rate was 20%.
Conclusions:
- Typhlitis is a significant concern in pediatric acute leukemia patients, with a notable mortality rate.
- Prompt diagnosis and aggressive medical management are essential to reduce morbidity and mortality associated with typhlitis.
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