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Subtypes of mild cognitive impairment among the elderly with major depressive disorder in remission

Yi-Chun Yeh1, Hin-Yeung Tsang, Pao-Yen Lin

  • 1Department of Psychiatry, Kaohsiung Medical University Hospital, Taiwan.

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
|October 26, 2011
PubMed
Abstract

Insights

Over half of elderly individuals with remitted depression show mild cognitive impairment (MCI), with distinct subtypes linked to different risk factors. Understanding these subtypes is crucial for dementia risk assessment.

Area of Science:

  • Neuroscience
  • Gerontology
  • Psychiatry

Background:

  • Cognitive impairment in late-life depression varies and may increase dementia risk.
  • This study investigates mild cognitive impairment (MCI) subtypes in remitted late-life depression.

Purpose of the Study:

  • Classify MCI subtypes in elderly patients with remitted major depressive disorder.
  • Examine clinical correlates and structural MRI features of these MCI subtypes.

Main Methods:

  • Evaluated elderly patients with remitted major depressive disorder and elderly comparisons using cognitive tasks.
  • Classified MCI using proposed diagnostic criteria.
  • Assessed brain atrophy and white matter hyperintensity via MRI.

Main Results:

  • Memory and information-processing speed were key cognitive domains affected.
  • 52.3% met MCI criteria: 28.5% amnestic MCI (aMCI), 23.8% nonamnestic MCI (naMCI).
  • Late-onset depression correlated with aMCI; stroke risk scale scores with naMCI. Ventricular atrophy linked to aMCI.

Conclusions:

  • Over half of subjects had MCI, with memory and processing speed deficits.
  • Distinct risk factors identified for aMCI (late-onset, atrophy) and naMCI (vascular risk).
  • Suggests differing pathogeneses for aMCI and naMCI in late-life depression.

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