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Updated: May 28, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Preoperative alpha blockade for normotensive pheochromocytoma: is it necessary?
Yuan Shao1, Ran Chen, Zhou-jun Shen
1Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Objective:
To compare the intraoperative hemodynamics in normotensive pheochromocytoma patients undergoing tumor resection between those with α-blockade preparation, preoperatively, and those without it.
Methods:
From January 2003 to July 2011, patients with adrenal incidentaloma, which was highly suspected as normotensive pheochromocytoma, were divided into two groups. Group 1 recieved α1-blockade doxazosin before adrenalectomy. Group 2 received no α-adrenoceptor, preoperatively. Data regarding the intraoperative hemodynamics was collected. These include peak/nadir blood pressure (BP) and heart rate, vasoactive medication and fluid infusion.
Results:
Fifty-nine cases of pheochromocytoma were confirmed by histopathology examination: 38 in group 1 and 21 in group 2. No differences were found in the preoperative demographics, comorbidities, BP and anesthesia. Intraoperative BP and heart rate showed no difference between these two groups. Intraoperative use of nitroglycerin (P < 0.001), norepinephrine (P < 0.001), phentolamine (P < 0.001) and colloid fluid (P = 0.008) was significantly greater in group 1 with doxazosin.
Conclusion:
Preoperative α1-adrenoceptor antagonist has no benefit in maintaining intraoperative hemodynamic stability in patients with normotensive pheochromocytoma. It may increase the use of vasoactive drugs and colloid infusion.
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