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Related Experiment Videos

Dopamine in gastrointestinal disease.

G B Glavin1, S Szabo

  • 1Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.

Digestive Diseases and Sciences
|September 1, 1990
PubMed
Summary

Dopamine plays a key role in regulating the digestive system, influencing ulcers, secretion, motility, and blood flow. Dopamine agonists show promise for treating gastrointestinal diseases via the brain-gut axis.

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Area of Science:

  • Neurogastroenterology
  • Pharmacology
  • Gastroenterology

Background:

  • Dopamine functions as a critical neuromodulator within the enteric nervous system.
  • The brain-gut axis integrates central and enteric signaling pathways.

Purpose of the Study:

  • To review evidence supporting dopamine's role in various gastrointestinal functions and diseases.
  • To explore the therapeutic potential of dopaminergic agents in gastrointestinal disorders.

Main Methods:

  • Literature review of studies on dopaminergic involvement in experimental gastrointestinal models.
  • Analysis of data concerning dopamine's effects on ulceration, secretion, motility, and blood flow.
  • Evaluation of the gastroprotective effects of dopamine agonists.

Main Results:

  • Dopamine influences experimental duodenal and gastric ulceration.
  • Dopaminergic activity impacts gastric, pancreatic, and duodenal secretion.
  • Dopamine modulates gastrointestinal motility and submucosal blood flow.
  • Selective dopamine agonists demonstrate gastroprotective properties.

Conclusions:

  • Dopamine is integral to the brain-gut axis.
  • Dopaminergic pathways represent a promising target for gastrointestinal pharmacotherapy.

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