Optimal sedative dose of propofol to start MRI in children with cerebral palsy
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Updated: May 28, 2026

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure
Published on: July 30, 2009
Eun Jung Kim1, Youn Yi Jo, Hae Keum Kil
1Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea.
Background:
This study was designed to determine the optimal sedative dose of propofol to start brain magnetic resonance imaging (MRI) in children with cerebral palsy (CP).
Methods:
Twenty children, aged 0.5-5 years, were administered propofol to achieve a University of Michigan Sedation Scale (UMSS) score ≥ 3 in the MRI room. The proper dose of propofol was determined using the up-and-down method.
Results:
The ED50 and ED95 for successful sedation with a UMSS ≥ 3 were 2.07 mg/kg (95% CI 1.69-2.56) and 2.69 mg/kg (95% CI 2.35-5.59). Respiratory events occurred in 5 patients and were resolved with neck extension, chin lift, or transient respiratory assistance with successful sedation.
Conclusions:
Low dose propofol can safely facilitate the initiation of MRI in children with CP.
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