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Related Concept Videos

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models00:57

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...

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Related Experiment Video

Updated: May 28, 2026

Simultaneous Evaluation of Cerebral Hemodynamics and Light Scattering Properties of the In Vivo Rat Brain Using Multispectral Diffuse Reflectance Imaging
07:06

Simultaneous Evaluation of Cerebral Hemodynamics and Light Scattering Properties of the In Vivo Rat Brain Using Multispectral Diffuse Reflectance Imaging

Published on: May 7, 2017

Born approximation model for light scattering by red blood cells.

Joonoh Lim, Huafeng Ding, Mustafa Mir

    Biomedical Optics Express
    |October 26, 2011
    PubMed
    Summary

    Researchers developed a novel method to rapidly assess red blood cell (RBC) morphology and volume distribution from blood smear images. This technique offers a faster, reliable alternative for blood screening and anemia diagnosis.

    Keywords:
    (070.7345) Wave propagation(100.2960) Image analysis(120.5820) Scattering Measurements(170.1470) Blood or tissue constituent monitoring(180.3170) Interference microscopy

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    Measurement of Particle Size Distribution in Turbid Solutions by Dynamic Light Scattering Microscopy

    Published on: January 9, 2017

    Area of Science:

    • Biomedical Engineering
    • Optical Imaging
    • Hematology

    Background:

    • Red blood cells (RBCs) are vital for oxygen transport; abnormalities cause anemia.
    • Diseases like malaria and sickle cell anemia impact RBC function.
    • Current blood screening methods can be slow and costly.

    Purpose of the Study:

    • To develop a rapid, reliable method for measuring RBC morphological parameters.
    • To enable simultaneous determination of average RBC volume and its standard deviation.
    • To advance label-free, high-throughput blood testing technologies.

    Main Methods:

    • Quantitative phase imaging of whole blood smears.
    • Modeling RBC shape using Born approximation.
    • Extracting morphological parameters like diameter, thickness, and dimple size.

    Main Results:

    • Accurate measurement of RBC diameter, thickness, and dimple size.
    • Simultaneous determination of average RBC volume and standard deviation.
    • Demonstrated potential for high-throughput analysis without individual cell tracking.

    Conclusions:

    • The developed method provides a faster and reliable approach to RBC analysis.
    • This technique can aid in diagnosing anemias and related disorders.
    • It paves the way for next-generation, label-free blood testing.