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Related Experiment Video

Updated: May 28, 2026

Construction of a High Resolution Microscope with Conventional and Holographic Optical Trapping Capabilities
09:12

Construction of a High Resolution Microscope with Conventional and Holographic Optical Trapping Capabilities

Published on: April 22, 2013

Combined acoustic and optical trapping.

G Thalhammer, R Steiger, M Meinschad

    Biomedical Optics Express
    |October 26, 2011
    PubMed
    Summary

    This study combines optical and acoustic trapping for precise micro-manipulation of cells. The integrated system enables simultaneous handling of single cells and larger particle populations in microfluidic devices.

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    Area of Science:

    • Biophysics
    • Microfluidics
    • Acoustic and Optical Trapping

    Background:

    • Conventional micro-manipulation methods like optical tweezers and acoustic trapping have limitations.
    • Optical tweezers excel at single-particle manipulation, while acoustic trapping handles larger populations.
    • Integrating these methods is challenging due to differing experimental requirements.

    Purpose of the Study:

    • To develop a combined optical and acoustic trapping system for micro-manipulation.
    • To overcome limitations of individual trapping methods by synergistic integration.
    • To enable precise handling of both single cells and larger particle groups within a microfluidic environment.

    Main Methods:

    • Utilized optical macro-tweezers with a large field of view and working distance.
    Keywords:
    (110.7170) Ultrasound(140.7010) Laser trapping(170.4520) Optical confinement and manipulation(350.4855) Optical tweezers or optical manipulation

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    Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers

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    Last Updated: May 28, 2026

    Construction of a High Resolution Microscope with Conventional and Holographic Optical Trapping Capabilities
    09:12

    Construction of a High Resolution Microscope with Conventional and Holographic Optical Trapping Capabilities

    Published on: April 22, 2013

    Optical Trapping of Nanoparticles
    13:39

    Optical Trapping of Nanoparticles

    Published on: January 15, 2013

    Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers
    09:56

    Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers

    Published on: August 31, 2021

  • Integrated optical tweezers with acoustic trapping in a microfluidic setup.
  • Characterized acoustic trapping forces using optically trapped particles.

    • Main Results:

    • Successfully combined optical and acoustic trapping for motile micro-organisms.
    • Demonstrated manipulation of large particles (up to 75 μm).
    • Achieved active particle sorting using the integrated system.

    Conclusions:

    • The combined system offers enhanced capabilities for micro-manipulation.
    • This integrated approach overcomes previous experimental constraints.
    • Enables versatile applications in handling and sorting micro-scale particles and organisms.