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Hyperinsulinemia and its sequelae.

D C Simonson1

  • 1Department of Internal Medicine, Joslin Diabetes Center, New England Deaconess Hospital, Boston, Massachusetts.

Hormone and Metabolic Research. Supplement Series
|January 1, 1990
PubMed
Summary

Insulin resistance and high insulin levels are linked to obesity, diabetes, hypertension, and heart disease. Chronic high insulin may contribute to these common health issues.

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Area of Science:

  • Endocrinology
  • Metabolic Syndrome
  • Cardiovascular Disease

Background:

  • Insulin resistance and hyperinsulinemia are hallmarks of obesity, type 2 diabetes, hypertension, and cardiovascular disease.
  • Emerging evidence indicates impaired insulin action in apparently healthy individuals.
  • The long-term effects of elevated insulin levels are under intense investigation.

Purpose of the Study:

  • To review the evidence supporting the hypothesis that insulin resistance and hyperinsulinemia are common pathophysiological factors.
  • To examine the adverse effects of chronic hyperinsulinemia.

Main Methods:

  • Review of existing scientific literature and clinical studies.
  • Analysis of data linking insulin resistance, hyperinsulinemia, and metabolic/vascular diseases.

Main Results:

  • Insulin resistance and hyperinsulinemia are prevalent in various common diseases.
  • Elevated insulin levels may be present even in healthy individuals.
  • A strong association exists between insulin dysregulation and metabolic and vascular disorders.

Conclusions:

  • Insulin resistance and hyperinsulinemia are implicated as common underlying factors in obesity, NIDDM, hypertension, and atherosclerosis.
  • Chronic hyperinsulinemia may have significant adverse health consequences.
  • Further research is warranted to fully understand the role of insulin in these conditions.

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