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Updated: May 28, 2026
Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT
Published on: November 23, 2012
[Optimization of the scan time is based on the physical index in FDG-PET/CT]
Naoki Shimada1, Hiromitsu Daisaki, Takeshi Murano
1Screening Technology and Development Division, Research Center for Cancer Prevention and Screening, National Cancer Center.
Purpose:
The image quality of Positron Emission Tomography (PET) using (18)F-fluoro-2-deoxy-D-glucose is extremely important to diagnose cancer precisely. The purpose of this study is to inspect the physical indexes that are correlated with image quality and optimization of the scan time, utilizing the physical index.
Methods:
This study calculated two kinds of patient noise equivalent counts (NEC(patient) and NEC(density)) and signal to noise ratio in liver (SNR(liver)) to measure PET image quality. We estimated the correlation coefficient between the visual assessment of PET image quality and physical indexes to assess the degree of correlation. We also set the optimal scan time, depending on body mass index (BMI), using the physical index and examined the efficacy of the optimization.
Results:
NEC(density) showed the highest correlation coefficient in PET image quality (r=0.743, p<0.001). By optimizing the scan time using NEC(density), we showed there was no correlation between BMI and NEC(density) (r=0.192, p=0.047). In addition, reduced dependence of the PET image quality by BMI was showed.
Conclusion:
The optimization of the scan time using NEC(density) reduces deterioration of the PET image quality by patient habitus.
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