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Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining

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The European gonococcal antimicrobial surveillance programme, 2009.

M J Cole¹, M Unemo, S Hoffmann

¹Health Protection Agency, London, United Kingdom. michelle.cole@hpa.org.uk

Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin

|October 27, 2011

Summary

This summary is machine-generated.

Antimicrobial resistance in Neisseria gonorrhoeae is increasing in Europe. The European gonococcal antimicrobial surveillance programme (Euro-GASP) found high resistance to ciprofloxacin and azithromycin, and reduced susceptibility to cefixime.

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Area of Science:

Microbiology
Public Health
Epidemiology

Background:

Neisseria gonorrhoeae antimicrobial susceptibility is monitored in the European Union (EU) and European Economic Area (EEA) via the European gonococcal antimicrobial surveillance programme (Euro-GASP).
Monitoring antimicrobial resistance is crucial for effective treatment and public health.
Emerging resistance patterns necessitate updated surveillance and treatment guidelines.

Purpose of the Study:

To report the antimicrobial susceptibility of Neisseria gonorrhoeae isolates in the EU/EEA in 2009.
To highlight trends in antimicrobial resistance, including decreased susceptibility to cefixime and high resistance to ciprofloxacin and azithromycin.
To outline the expansion and future directions of the Euro-GASP program for enhanced surveillance.

Main Methods:

Data collection from 17 EU/EEA Member States participating in the Euro-GASP network.
Analysis of antimicrobial susceptibility testing results for Neisseria gonorrhoeae isolates.
Monitoring trends in minimum inhibitory concentrations (MICs) for key antibiotics.

Main Results:

In 2009, 5% of Neisseria gonorrhoeae isolates showed decreased susceptibility to cefixime.
An upward trend in the minimum inhibitory concentrations of ceftriaxone was observed.
High prevalence of resistance was noted for ciprofloxacin (63%) and azithromycin (13%).

Conclusions:

The findings underscore the public health importance of Neisseria gonorrhoeae antimicrobial resistance.
Healthcare professionals must be aware of potential cefixime treatment failures due to emerging resistance.
Enhancements to Euro-GASP, including biannual reporting and linked data, will improve timely detection of resistance trends and inform therapeutic guidelines.