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Hematopoiesis

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

Production of Formed Elements

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

Overview of Hematopoiesis

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...

Lineage Commitment

Lineage Commitment

Commitment is the process whereby stem cells:

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Related Experiment Video

Updated: May 28, 2026

Isolation of Murine Embryonic Hemogenic Endothelial Cells

Isolation of Murine Embryonic Hemogenic Endothelial Cells

Published on: June 17, 2016

[Endothelial origin for hematopoietic stem cells: a visual proof].

Jean-Charles Boisset¹, Catherine Robin

¹Erasmus Stem Cell Institute, Department of Cell Biology, Erasmus Medical Center, Rotterdam, Pays-Bas.

Medecine Sciences : M/S

|October 27, 2011

Summary

This summary is machine-generated.

Hematopoietic stem cells (HSCs) are crucial for lifelong blood production. Their exact embryonic origin is debated, with ongoing research exploring various precursor candidates and anatomical sites.

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Last Updated: May 28, 2026

Isolation of Murine Embryonic Hemogenic Endothelial Cells

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Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition

Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition

Published on: June 16, 2019

Area of Science:

Developmental biology
Hematopoiesis
Stem cell research

Context:

Hematopoietic stem cells (HSCs) are essential for generating all blood cell types throughout an organism's life.
HSCs originate during embryonic development and migrate through various hematopoietic organs to the bone marrow.
The precise embryonic origin of HSCs is a complex and debated topic in the scientific community.

Purpose:

To review and discuss current theories on the origin of hematopoietic stem cells.
To analyze recent findings, particularly those employing in vivo confocal microscopy, to shed light on HSC origins.
To synthesize existing knowledge and identify areas of controversy regarding HSC precursor candidates.

Summary:

This review examines the different proposed origins of hematopoietic stem cells (HSCs) during embryonic development.
It discusses various candidate precursor populations and their anatomical locations.
Emphasis is placed on recent studies utilizing advanced imaging techniques like in vivo confocal microscopy.

Impact:

Provides a comprehensive overview of the current understanding and controversies surrounding HSC origins.
Highlights the importance of advanced imaging technologies in resolving developmental biology questions.
Contributes to the foundational knowledge required for regenerative medicine and stem cell therapies.