Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Liquid ventilation during early development: theory, physiologic processes and application.

M R Wolfson1, T H Shaffer

  • 1Temple University School of Medicine, Department of Physiology, Philadelphia, PA 19140.

Journal of Developmental Physiology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oxygen saturation and work of breathing indices in preterm infants with bronchopulmonary dysplasia compared to healthy preterm infants at discharge.

Journal of neonatal-perinatal medicine·2024
Same author

The impact of kangaroo mother care on work of breathing and oxygen saturation in very low birth weight infants with respiratory insufficiency.

Journal of neonatal-perinatal medicine·2022
Same author

A novel in-line high frequency interrupter for use with bubble CPAP: A feasibility study in a premature lamb model.

Journal of neonatal-perinatal medicine·2022
Same author

Effects of xenon gas on human airway epithelial cells during hyperoxia and hypothermia.

Journal of neonatal-perinatal medicine·2020
Same author

Pulmonary mechanics measurements by respiratory inductive plethysmography and esophageal manometry: Methodology for infants on non-invasive respiratory support.

Journal of neonatal-perinatal medicine·2019
Same author

High flow nasal heliox improves work of breathing and attenuates lung injury in a newborn porcine lung injury model.

Journal of neonatal-perinatal medicine·2016
Same journal

Analysis of beat-to-beat heart rate changes during sleep-waking states in normal infants.

Journal of developmental physiology·1993
Same journal

Modification of thermogenic capacity in neonatal pigs by changes in thyroid status during late gestation.

Journal of developmental physiology·1993
Same journal

Decreased norepinephrine turnover rate in the brown adipose tissue of pre-obese fa/fa Zucker rats.

Journal of developmental physiology·1993
Same journal

Thyroid hormone status correlates inversely with expression of the growth hormone receptor gene in rats immediately after birth.

Journal of developmental physiology·1993
Same journal

Inotropic effects of ryanodine and calcium antagonists on embryonic and hatched chick myocardium.

Journal of developmental physiology·1993
Same journal

Abdominal vibration alters sleep state in fetal sheep.

Journal of developmental physiology·1993
See all related articles

Liquid ventilation offers a promising approach to support preterm infants transitioning to extrauterine life. This method aids lung development and improves respiratory function, enhancing survival rates for premature neonates.

Area of Science:

  • Neonatology
  • Pulmonary Physiology
  • Experimental Medicine

Background:

  • Extrauterine viability is compromised in preterm infants due to pulmonary system immaturity.
  • Incomplete lung biochemical development leads to surfactant deficiency, alveolar instability, and poor gas exchange.
  • Conventional ventilation methods are inadequate for studying preterm physiology before 85% gestation.

Purpose of the Study:

  • To explore the potential of liquid ventilation for supporting preterm infants.
  • To investigate the physiological effects of liquid ventilation in preterm animal models.
  • To present the evolution of liquid ventilation as an experimental and potential clinical tool.

Main Methods:

  • Application of liquid ventilation principles to preterm and newborn animals since the early 1970s.

Related Experiment Videos

  • Technological advancements in liquid delivery systems.
  • Utilizing liquid ventilation to support animals during the intrauterine to extrauterine transition.

    • Main Results:

    • Liquid ventilation reduces surface tension and improves lung mechanics.
    • Effective pulmonary gas exchange and acid-base balance are achieved.
    • Enhanced pulmonary blood flow distribution and cardiovascular stability are observed in liquid-ventilated preterm animals.

    Conclusions:

    • Liquid ventilation is a viable experimental tool for studying preterm physiology.
    • This method demonstrates potential as a clinical therapeutic modality for early development.
    • Liquid ventilation supports critical physiological functions during the transition to extrauterine life.