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Diagnostic implications of p16 expression in serous papillary endometrial cancer
Itamar M Netzer1, Hedwiga Kerner, Ludmila Litwin
1Gynecologic Oncology Unit, Department of Gynecology and Obstetrics, Rambam Medical Center, Haifa, Israel. I_netzer@rambam.health.gov.il
Objective:
The purpose of this study was to examine whether the degree of expression of the p16 protein in serous papillary endometrial cancer bears a prognostic significance. The secondary objective was to establish the value of p16 immunohistochemical staining as an adjunct to diagnosis.
Study Design:
Archived paraffin blocks holding specimens from the uteri of 31 serous papillary and 31 endometrioid endometrial carcinoma patients were recut and restained for p16 and p53.
Results:
Overexpression of p16 was found in 78% of the serous papillary patients versus 36% of the endometrioid patients. p16 was not found to be an independent prognostic factor in serous papillary endometrial carcinoma.
Conclusions:
Although p16 was not found to have prognostic significance in serous papillary endometrial carcinoma, it may be valuable as a diagnostic adjunct in histologically ambiguous tumors.