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Frontal sinus lymphoma presenting as progressive multiple cranial nerve palsy
Kyubo Kim1, Min Ju Kim, Sanghyeon Ahn
1Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul , Korea.
Yonsei Medical Journal
|October 27, 2011
Summary
Primary frontal sinus lymphoma is rare, often presenting with mass effect. This case highlights an unusual presentation of facial palsy due to diffuse large B cell lymphoma, successfully treated with stem cell transplantation.
Area of Science:
- Oncology
- Neurology
- Otorhinolaryngology
Background:
- Primary frontal sinus lymphoma is an exceedingly rare malignancy.
- Most reported cases present with symptoms related to tumor mass effect.
- Diffuse large B cell lymphoma is the most common type of non-Hodgkin lymphoma.
Observation:
- An immunocompetent patient presented with facial palsy, followed by progressive cranial nerve palsies.
- The patient was diagnosed with diffuse large B cell lymphoma originating in the frontal sinus.
- Initial symptoms were atypical, not solely due to mass effect.
Findings:
- The patient received chemotherapy followed by autologous peripheral blood stem cell transplantation.
- The described treatment regimen led to a disease-free outcome.
- This case demonstrates an unusual neurological presentation of frontal sinus lymphoma.
Implications:
- Highlights the importance of considering rare diagnoses in cases of unexplained cranial nerve palsies.
- Suggests that frontal sinus lymphoma can present with neurological deficits beyond mass effect.
- Emphasizes the efficacy of aggressive treatment protocols, including stem cell transplantation, for refractory or advanced cases.
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