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Updated: May 28, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

[Asymptomatic proteinuria in children]

Martino Marsciani1, Andrea Pasini, Giovanni Montini

  • 1Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy.

Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
|October 27, 2011
PubMed

Insights

Asymptomatic proteinuria in children often does not indicate kidney disease. Persistent proteinuria requires evaluation by a pediatric nephrologist to diagnose and treat potential renal damage.

Area of Science:

  • Pediatric Nephrology
  • Clinical Urinalysis
  • Primary Care

Context:

  • Asymptomatic proteinuria is frequently identified during routine screening urinalysis in children.
  • Most cases of asymptomatic proteinuria do not signify underlying kidney disease.
  • Differentiating transient, orthostatic, and persistent proteinuria is crucial for appropriate management.

Purpose:

  • To outline the diagnostic approach to asymptomatic proteinuria in pediatric primary care.
  • To differentiate between transient, orthostatic, and persistent proteinuria.
  • To guide referral decisions for children with proteinuria.

Summary:

  • Transient proteinuria, often linked to fever or stress, resolves upon removal of the trigger.
  • Orthostatic proteinuria is a common, benign condition in school-aged children.
  • Persistent proteinuria is a significant marker of renal damage and necessitates further investigation and specialist referral.

Impact:

  • This approach aims to reduce unnecessary investigations in children with benign proteinuria.
  • Early identification and management of persistent proteinuria can prevent long-term kidney damage.
  • Facilitates timely referral to pediatric nephrologists for accurate diagnosis and treatment.

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