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Related Concept Videos

Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...

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Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
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Published on: July 5, 2021

Update on meningiomas.

Santosh Saraf1, Bridget J McCarthy, J Lee Villano

  • 1Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.

The Oncologist
|October 27, 2011
PubMed
Summary
This summary is machine-generated.

Meningiomas, the most common central nervous system tumors, show increasing incidence with age and a female predilection. Limited treatment advances exist, with ongoing research into novel therapies.

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Area of Science:

  • Neuro-oncology
  • Central Nervous System (CNS) Tumors

Background:

  • Meningiomas are the most frequent primary tumors of the central nervous system.
  • Historically, their incidence, epidemiology, and clinical outcomes have been poorly defined due to benign behavior, diagnostic challenges, and lack of standardized data.
  • Clinical presentation varies widely, from asymptomatic incidental findings to life-threatening conditions.

Purpose of the Study:

  • To review the current understanding of meningioma incidence, epidemiology, and clinical outcomes.
  • To highlight the impact of an aging population on meningioma prevalence.
  • To discuss current and emerging therapeutic strategies for meningiomas.

Main Methods:

  • Literature review and synthesis of existing data on meningioma epidemiology and clinical management.
  • Analysis of factors influencing meningioma risk, including age, sex, and radiation exposure.
  • Overview of current treatment modalities and investigational therapies.

Main Results:

  • Meningioma incidence is projected to rise with an aging population.
  • The disease predominantly affects older individuals and has a higher prevalence in females.
  • Ionizing radiation exposure is a known risk factor.
  • Treatment options remain limited, with radiation therapy showing some advances, while systemic therapies like hydroxyurea and sandostatin are used off-label.
  • No FDA-approved targeted therapies have shown clinical benefit, despite identified molecular alterations.

Conclusions:

  • Meningiomas represent a significant and growing public health concern, particularly in aging populations.
  • Current treatment strategies are largely supportive, with limited efficacy for advanced or recurrent disease.
  • Further research into molecular alterations is crucial for developing effective targeted therapies.