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Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
Published on: July 2, 2013
Global aphasia without hemiparesis: A case series
Aparna R Pai1, Gopee Krishnan, S Prashanth
1Department of Neurology, Kasturba Medical College, Manipal College of Allied Health Sciences, Manipal, India.
Annals of Indian Academy of Neurology
|October 27, 2011
Summary
Global aphasia without hemiparesis (GAWH) can stem from various stroke types and lesion locations. Recovery patterns in GAWH are variable and may challenge traditional brain language models.
Area of Science:
- Neuroscience
- Neurology
- Stroke Medicine
Background:
- Global aphasia without hemiparesis (GAWH) is a rare stroke syndrome.
- It presents with a unique dissociation of motor and language functions.
- Its pathogenesis, lesion sites, and recovery are debated.
Purpose of the Study:
- To retrospectively analyze four cases of GAWH caused by ischemic stroke.
- To investigate lesion characteristics, etiology, and recovery patterns in GAWH patients.
Main Methods:
- Retrospective analysis of four GAWH patients admitted between 2005-2009.
- Emphasis on lesion number, site, etiology, and observed recovery.
Main Results:
- GAWH can result from single or multiple lesions, including subcortical ones.
- Recovery was rapid but incomplete, with varied aphasia evolution (Wernicke's, transcortical sensory, Broca's).
- Two cases showed a lack of clinico-anatomic correlation during recovery.
Conclusions:
- GAWH can arise from embolic or large vessel strokes with diverse lesion types.
- Variable recovery patterns and lack of clinico-anatomical correlation suggest anomalous brain reorganization.
- Findings challenge conventional models of language representation in the brain.
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