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Induction of Petite Colonies in Candida glabrate via Rose Bengal-Mediated Photodynamic Therapy

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Fluconazole induced fixed drug eruption.

Chi Yeon Kim¹, Jin Gu Kim, Chee Won Oh

¹Department of Dermatology, School of Medicine, Gyeongsang National University & Gyeongsang Institute of Health Science, Jinju, Korea.

Annals of Dermatology

|October 27, 2011

Summary

This summary is machine-generated.

A rare case of fluconazole-induced fixed drug eruption was observed in a 62-year-old female patient. Oral provocation confirmed the diagnosis, highlighting a unique presentation in dermatologic literature.

Keywords:

Drug eruption Fluconazole

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Area of Science:

Dermatology
Pharmacovigilance

Background:

Fixed drug eruption (FDE) is a specific type of adverse drug reaction.
Antifungal medications, such as fluconazole, can rarely cause FDE.

Observation:

A 62-year-old female presented with recurrent, itchy, erythematous maculopatches on her face, neck, arms, and trunk over six months.
The patient had been prescribed oral fluconazole for onychomycosis.

Findings:

Patch testing for fluconazole yielded negative results.
Oral provocation with fluconazole was positive, confirming fluconazole as the causative agent for the fixed drug eruption.
This represents the first reported case of fluconazole-induced FDE in Korean dermatologic literature.

Implications:

This case underscores the importance of considering FDE even with negative patch tests.
Oral provocation remains a crucial diagnostic tool for suspected FDE.
Clinicians should be aware of fluconazole as a potential cause of FDE, particularly in cases with recurrent lesions.