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Photodistributed telangiectasia induced by amlodipine
Ji Won Byun1, Chan Il Bang, Bo Hee Yang
1Department of Dermatology, Inha University School of Medicine, Incheon, Korea.
Annals of Dermatology
|October 27, 2011
Summary
Calcium channel blockers, like amlodipine, can rarely cause skin reactions. This case highlights amlodipine-induced photosensitive telangiectasia, a rare side effect involving enlarged capillaries.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Calcium channel blockers (CCBs) are common antihypertensive medications.
- Cutaneous reactions to CCBs, including pruritus, urticaria, and alopecia, are infrequent.
- Photosensitivity with telangiectasia is a rarely documented adverse effect of CCBs.
Observation:
- A case study identified a patient experiencing photodistributed telangiectasia.
- The patient was clinically diagnosed with amlodipine-induced photosensitivity.
- Histological examination revealed enlarged capillaries in the upper dermis, without evidence of vasculitis.
Findings:
- Amlodipine, a dihydropyridine calcium channel blocker, was identified as the causative agent.
- The reaction manifested as telangiectasia in sun-exposed areas.
- Histopathology confirmed vascular changes consistent with the clinical presentation.
Implications:
- This case expands the known spectrum of cutaneous adverse reactions to amlodipine.
- Clinicians should consider amlodipine as a potential cause of photosensitive telangiectasia.
- Further research may elucidate the mechanism of this rare photosensitivity reaction.
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