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Updated: May 28, 2026
Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy
Published on: June 29, 2021
Clinical experience with a novel bovine collagen dura mater substitute
Bruno Silva Costa1, George de Albuquerque Cavalcanti-Mendes, Marcelo Sartori de Abreu
1Department of Neurosurgery, Hospital Santa Casa de Belo Horizonte, Minas Gerais, Brazil.
Background:
Dural substitutes are used to achieve a watertight closure in situations where adequate closure is not possible .This study was conducted to evaluate the efficacy and safety of use a new collagen matrix dural substitute ( Duradry, Tecnodry, Belo Horizonte MG) in repair or expansion of cranial and spinal dura-mater.
Methods:
30 patients operated on between March and September 2008, were studied. Surgical logs were reviewed for sex, age, diagnosis, location of the graft, technique and presence of fistula or infection. The patients were followed-up for at least 3 months, and the presence of complications as cerebrospinal leakage, infection, aseptic meningitis, hydrocephalus, pseudomeningocele were analysed.
Results:
Only one patient presented with CSF fistula. No patients presented with wound infections, hydrocephalus, pseudomeningocele, meningitis, brain abscesses or signs of toxicity related to the material.
Conclusions:
The new dural substitute used in this study is effective and safe, and the initial results are similar to those of other dural substitutes reported in the literature.
