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The course of D-dimer, high-sensitivity C-reactive protein and pro-B-type natriuretic peptide in patients with

S Ghanavatian1, R A Stein, D Atar

  • 1Division of Cardiology, Department of Medicine, Oslo University Hospital Aker, Oslo University, Oslo, Norway.

Clinical Laboratory
|October 28, 2011
PubMed

Insights

In patients with Non-ST-Elevation Myocardial Infarction (NSTEMI), D-dimer and pro-BNP levels remained stable in the first 12 hours. However, high-sensitivity C-reactive protein (hs-CRP) levels significantly decreased by 12 hours post-admission.

Area of Science:

  • Cardiology
  • Biomarker Research

Background:

  • Elevated high-sensitivity C-reactive protein (hs-CRP), B-type natriuretic peptide (BNP), and D-dimer are linked to adverse outcomes in acute myocardial infarction (AMI).
  • Understanding the temporal changes of these biomarkers in Non-ST-Elevation Myocardial Infarction (NSTEMI) is crucial for patient management.

Purpose of the Study:

  • To investigate the dynamic changes of D-dimer, hs-CRP, and pro-BNP in patients diagnosed with NSTEMI within the initial 12 hours of hospital admission.

Main Methods:

  • Prospective study involving 82 patients with suspected acute coronary syndrome (ACS).
  • 40 patients were diagnosed with NSTEMI; the rest had AMI ruled out.
  • Blood samples were collected at admission, 6 hours, and 12 hours post-admission for hs-CRP, pro-BNP, and D-dimer analysis using a point-of-care system.

Main Results:

  • No significant changes in D-dimer or pro-BNP levels were observed between admission and 12 hours in NSTEMI patients.
  • A statistically significant decrease in hs-CRP levels was noted at 12 hours compared to admission values (p=0.04).

Conclusions:

  • D-dimer and pro-BNP do not exhibit dynamic changes within the first 12 hours of admission in acute NSTEMI patients.
  • hs-CRP levels show a decreasing trend within 12 hours post-admission in NSTEMI patients.
Abstract

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