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Updated: May 28, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Design and synthesis of some novel hydrazide, 1,2-dihydropyridine, chromene derivatives carrying biologically active
Mahmoud S Bashandy1, Mansour S Al-Said, Saleh I Al-Qasoumi
1Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.
Abstract:
This paper describes the synthesis of some novel sulfones having biologically active hydrazides (4-9, 22, 23, 26 and 27), hydrazonoyl cyanide (24), 1,2-dihydropyridines (16-21), chromene (28) and benzochromene (29) moieties starting with 1-[4-(piperidin-1-ylsulfonyl)phenyl]-ethanone 1. The structures of the the newly synthesized compounds were confirmed by elemental analysis, IR, 1H NMR and 13C NMR. All the newly synthesized compounds were evaluated for their in vitro anticancer activity against breast cancer cell line (MCF7).
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